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Enhancing Protein-Protein Interaction Prediction with Hierarchical Motif-based Multimodal Protein Embedding

Zaifei Yang, Samuel Ping-Man Choi, James Kwok
Jun 3, 2026 at 04:00
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arXiv:2606.02629v1 Announce Type: cross Abstract: Protein-protein interactions (PPIs) are essential for many biological processes. However, existing PPI prediction approaches suffer from two major limitations: they overlook the hierarchical organization of proteins, particularly meso-scale motifs that critically regulate PPIs, and fail to...

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